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Magnesium Breakthrough

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  • Best magnesium supplements for sleep*
  • Promotes a balanced stress response, feel relaxed and at peace*
  • Sleep faster and deeper*
  • A key nutrient for healthy immune responses*
  • Provides an essential electrolyte to maintain healthy rhythm*
  • Provides a key building block to strong bones*
  • OVER 35 SCIENTIFIC STUDIES DONE! Check the links at the bottom of the product page!

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Why Getting ALL 7 Forms of Magnesium Matters

One of the biggest misconceptions about magnesium is that that you just “need more” of it to help optimize your well-being.

But the TRUTH is, there are many different types of magnesium — and each plays an important role in different functions in your body.

Magnesium Orotate

While it also may be helpful for maintaining cardiovascular health, magnesium orotate may also support metabolic processes.*

This makes it a favorite for athletes seeking recovery, energy, and performance support.*

Getting ALL of these forms of magnesium, in the optimum dose, may support several functions in your body.* 

Magnesium Chelate

This form of magnesium is especially important for muscle building, recovery, and health.*


Magnesium Citrate

This form of magnesium supports metabolic health (how well the body generates and processes energy). One study found that this form may improve blood vessel health in healthy overweight individuals.*


Magnesium Bisglycinate

This is the best form of magnesium for overall relaxation responses. ​


Magnesium Malate

Some believe this to be the most bioavailable form of magnesium. It’s found naturally in fruits, giving them their tart taste.  


Sucrosomial® Magnesium

This form of magnesium is highly absorbed. It supports the immune system and bone health.


Magnesium Taurate  

This is the form of magnesium that is best for your heart.

One study noted: “The complex magnesium taurate may thus have considerable potential as a vascular-protective nutritional supplement.”


Magnesium Breakthrough Benefits


Supports Vitamin D Activation and Metabolism

Both Vitamin D and magnesium have important roles in bone health, immune function, and metabolism. Magnesium is a cofactor in vitamin D conversion and activation.[25] Some people cannot increase their blood 25-hydroxy vitamin D levels despite supplementing with vitamin D3 because they are deficient in magnesium. In other words, magnesium deficiency can make vitamin D less effective.

Also, in people deficient in magnesium, high doses of vitamin D3 could worsen magnesium deficiency and increase the potential for side effects of excessive vitamin D3, such as having calcium deposits in the arteries.


Improves the Ability to Deal With Stress and Helps to Relax

A magnesium supplement significantly reduces stress[3] in people who are deficient in magnesium. Also, combined[4] with vitamin B6 was 40% more helpful than alone in very stressful situations. Findings support the need for magnesium supplementation for people living in conditions of chronic stress.[5]

Helps With Mood, Cognitive Function, and Mental Health

A magnesium supplement significantly improved[6] mood[7] after 2 weeks. Another trial found that magnesium supplements improved[8] mood in seniors.

Promotes Heart Health

Magnesium is extremely important for heart health[2] and blood vessel health. Magnesium deficiency seems to worsen the inflammation, blood vessel constriction, blood clotting, and stress responses that trigger heart conditions. Correcting deficiency appears to improve heart health and reduces risk of death, although it is unclear whether supplementation alone is sufficient to treat these conditions.


Promotes Healthy Blood Sugar Hormone Function And Promotes Healthy Metabolism

Magnesium is important for hormones that regulate blood sugar[9] to function well. Therefore, many people with blood sugar issues and[10] metabolic syndrome are deficient in magnesium. Even when the blood sugar[11] is well-controlled, a supplement would still be necessary to achieve healthy levels. In a clinical trial involving 65 diabetes patients, magnesium supplementation promotes healthy function[12] and metabolism.

A large-scale systematic and dose-response analysis found that magnesium supplementation correlated with reduced body weight[13] and waist circumference among specific groups of people. Participants seemed to weigh less and had smaller waist circumference if they took magnesium supplements.

Magnesium on its own doesn’t cure blood sugar problems or cause weight loss, but it can be highly beneficial in combination with diet and exercise.

Supports Exercise Performance and Recovery

Magnesium supplementation improves speed and strength,[15] possibly by making glucose metabolism more efficient. It also supports healthy stress response to exercise, counteracts excessive muscle damage,[16] and improves exercise recovery (400 mg/day, taken at breakfast).


Builds Stronger Bones

Magnesium are key building blocks of your bones.[18] Magnesium deficiency can contribute to osteoporosis by:

  • preventing healthy bone formation, creating brittle bones
  • causing low-grade inflammation
  • increasing cortisol, which can contribute to bone loss
  • reducing parathyroid hormone

In a clinical trial[19] involving 73,684 postmenopausal women, low magnesium intake was associated with lower bone density in the hip and whole body. Magnesium intake slightly higher than the Recommended Dietary Allowance was associated with lower arm and wrist fractures from falling.
While magnesium is essential for bone health, magnesium supplements alone may not cure osteoporosis or osteopenia. Please speak to your doctor for diagnosis and treatments.

 

Improves Sleep Quality

In a small clinical trial involving 46 elderly subjects with sleep struggles,[17] 500 mg of daily magnesium supplement improved sleep quality, sleep latency, and cortisol. Subjects also had more serum melatonin, slept deeper, and were less likely to wake up in the middle of the night.


Promotes Healthy Blood Pressure

A meta-analysis of 34 randomized control trials found that magnesium reduced blood pressure.[20] However, the effect size is clinically small (<2 mmHg). Therefore, it may be good for supporting overall health and healthy blood pressure, but you may also need other interventions to achieve healthy blood pressure levels.  


Promotes Balanced and Healthy Immune System  

Magnesium deficiency[21]contributes to increased inflammation and weak immune responses.[22] In a meta-analysis[23] involving 32,198 people, those with more magnesium had less serum C-reactive protein (a marker of inflammation).

Overall, magnesium deficiencies tend to exacerbate or increase the risk of conditions that involve chronic inflammation.[24]

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Scientific Studies

  1. de Baaij JH, Hoenderop JG, Bindels RJ. Magnesium in man: implications for health and disease. Physiol Rev. 2015;95(1):1-46. doi:10.1152/physrev.00012.2014
  2. DiNicolantonio JJ, Liu J, O'Keefe JH. Magnesium for the prevention and treatment of cardiovascular disease. Open Heart. 2018;5(2):e000775. Published 2018 Jul 1. doi:10.1136/openhrt-2018-000775
  3. Boyle NB, Lawton C, Dye L. The Effects of Magnesium Supplementation on Subjective Anxiety and Stress-A Systematic Review. Nutrients. 2017;9(5):429. Published 2017 Apr 26. doi:10.3390/nu9050429
  4. Pouteau E, Kabir-Ahmadi M, Noah L, et al. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial. PLoS One. 2018;13(12):e0208454. Published 2018 Dec 18. doi:10.1371/journal.pone.0208454
  5. Eby GA, Eby KL. Rapid recovery from major depression using magnesium treatment. Med Hypotheses. 2006;67(2):362-370. doi:10.1016/j.mehy.2006.01.047
  6. Tarleton EK, Littenberg B, MacLean CD, Kennedy AG, Daley C. Role of magnesium supplementation in the treatment of depression: A randomized clinical trial. PLoS One. 2017;12(6):e0180067. Published 2017 Jun 27. doi:10.1371/journal.pone.0180067
  7. Botturi A, Ciappolino V, Delvecchio G, Boscutti A, Viscardi B, Brambilla P. The Role and the Effect of Magnesium in Mental Disorders: A Systematic Review. Nutrients. 2020;12(6):1661. Published 2020 Jun 3. doi:10.3390/nu12061661
  8. Barragán-Rodríguez L, Rodríguez-Morán M, Guerrero-Romero F. Efficacy and safety of oral magnesium supplementation in the treatment of depression in the elderly with type 2 diabetes: a randomized, equivalent trial. Magnes Res. 2008;21(4):218-223.
  9. Guerrero-Romero F, Tamez-Perez HE, González-González G, et al. Oral magnesium supplementation improves sensitivity in non-diabetic subjects with resistance. A double-blind placebo-controlled randomized trial. Diabetes Metab. 2004;30(3):253-258. doi:10.1016/s1262-3636(07)70116-7
  10. Takaya J, Higashino H, Kobayashi Y. Intracellular magnesium and resistance. Magnes Res. 2004;17(2):126-136.
  11. Schnack C, Bauer I, Pregant P, Hopmeier P, Schernthaner G. Hypomagnesaemia in type 2 diabetes mellitus is not corrected by improvement of long-term metabolic control. Diabetologia. 1992;35(1):77-79. doi:10.1007/BF00400855
  12. Rodríguez-Morán M, Guerrero-Romero F. Oral magnesium supplementation improves sensitivity and metabolic control in type 2 diabetic subjects: a randomized double-blind controlled trial. Diabetes Care. 2003;26(4):1147-1152. doi:10.2337/diacare.26.4.1147
  13. Askari M, Mozaffari H, Jafari A, Ghanbari M, Darooghegi Mofrad M. The effects of magnesium supplementation on obesity measures in adults: a systematic review and dose-response meta-analysis of randomized controlled trials [published online ahead of print, 2020 Jul 11]. Crit Rev Food Sci Nutr. 2020;1-17. doi:10.1080/10408398.2020.1790498
  14. Asemi Z, Karamali M, Jamilian M, et al. Magnesium supplementation affects metabolic status and pregnancy outcomes in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2015;102(1):222-229. doi:10.3945/ajcn.114.098616
  15. Zhang Y, Xun P, Wang R, Mao L, He K. Can Magnesium Enhance Exercise Performance?. Nutrients. 2017;9(9):946. Published 2017 Aug 28. doi:10.3390/nu9090946
  16. Córdova A, Mielgo-Ayuso J, Roche E, Caballero-García A, Fernandez-Lázaro D. Impact of Magnesium Supplementation in Muscle Damage of Professional Cyclists Competing in a Stage Race. Nutrients. 2019;11(8):1927. Published 2019 Aug 16. doi:10.3390/nu11081927
  17. Abbasi B, Kimiagar M, Sadeghniiat K, Shirazi MM, Hedayati M, Rashidkhani B. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. J Res Med Sci. 2012;17(12):1161-1169.
  18. Castiglioni S, Cazzaniga A, Albisetti W, Maier JA. Magnesium and osteoporosis: current state of knowledge and future research directions. Nutrients. 2013;5(8):3022-3033. Published 2013 Jul 31. doi:10.3390/nu5083022
  19. Orchard TS, Larson JC, Alghothani N, et al. Magnesium intake, bone mineral density, and fractures: results from the Women's Health Initiative Observational Study. Am J Clin Nutr. 2014;99(4):926-933. doi:10.3945/ajcn.113.067488
  20. Zhang X, Li Y, Del Gobbo LC, et al. Effects of Magnesium Supplementation on Blood Pressure: A Meta-Analysis of Randomized Double-Blind Placebo-Controlled Trials. Hypertension. 2016;68(2):324-333. doi:10.1161/HYPERTENSIONAHA.116.07664
  21. Tam M, Gómez S, González-Gross M, Marcos A. Possible roles of magnesium on the immune system. Eur J Clin Nutr. 2003;57(10):1193-1197. doi:10.1038/sj.ejcn.1601689
  22. Moslehi N, Vafa M, Rahimi-Foroushani A, Golestan B. Effects of oral magnesium supplementation on inflammatory markers in middle-aged overweight women. J Res Med Sci. 2012;17(7):607-614.
  23. Kim DJ, Xun P, Liu K, et al. Magnesium intake in relation to systemic inflammation, resistance, and the incidence of diabetes. Diabetes Care. 2010;33(12):2604-2610. doi:10.2337/dc10-0994
  24. Nielsen FH. Magnesium deficiency and increased inflammation: current perspectives. J Inflamm Res. 2018;11:25-34. Published 2018 Jan 18. doi:10.2147/JIR.S136742
  25. Uwitonze AM, Razzaque MS. Role of Magnesium in Vitamin D Activation and Function. J Am Osteopath Assoc. 2018;118(3):181-189. doi:10.7556/jaoa.2018.037
  26. Sartori SB, Whittle N, Hetzenauer A, Singewald N. Magnesium deficiency induces anxiety and HPA axis dysregulation: modulation by therapeutic drug treatment. Neuropharmacology. 2012;62(1):304-312. doi:10.1016/j.neuropharm.2011.07.027
  27. Jacka FN, Overland S, Stewart R, Tell GS, Bjelland I, Mykletun A. Association between magnesium intake and depression and anxiety in community-dwelling adults: the Hordaland Health Study. Aust N Z J Psychiatry. 2009;43(1):45-52. doi:10.1080/00048670802534408
  28. Grases G, Pérez-Castelló JA, Sanchis P, et al. Anxiety and stress among science students. Study of calcium and magnesium alterations. Magnes Res. 2006;19(2):102-106.
  29. Takase B, Akima T, Uehata A, Ohsuzu F, Kurita A. Effect of chronic stress and sleep deprivation on both flow-mediated dilation in the brachial artery and the intracellular magnesium level in humans. Clin Cardiol. 2004;27(4):223-227. doi:10.1002/clc.4960270411
  30. Boyle NB, Lawton C, Dye L. The Effects of Magnesium Supplementation on Subjective Anxiety and Stress-A Systematic Review. Nutrients. 2017;9(5):429. Published 2017 Apr 26. doi:10.3390/nu9050429
  31. Caillard, V. (1992). Sanofi Internal report MAB6-32. Paris, France. Unpublished work.
  32. Boyle NB, Lawton C, Dye L. The Effects of Magnesium Supplementation on Subjective Anxiety and Stress-A Systematic Review. Nutrients. 2017;9(5):429. Published 2017 Apr 26. doi:10.3390/nu9050429
  33. Pouteau E, Kabir-Ahmadi M, Noah L, et al. Superiority of magnesium and vitamin B6 over magnesium alone on severe stress in healthy adults with low magnesemia: A randomized, single-blind clinical trial. PLoS One. 2018;13(12):e0208454. Published 2018 Dec 18. doi:10.1371/journal.pone.0208454
  34. Bøhmer T, Røseth A, Holm H, Weberg-Teigen S, Wahl L. Bioavailability of oral magnesium supplementation in female students evaluated from elimination of magnesium in 24-hour urine. Magnes Trace Elem. 1990;9(5):272-278.
  35. Firoz M, Graber M. Bioavailability of US commercial magnesium preparations. Magnes Res. 2001;14(4):257-262.
  36. Uysal N, Kizildag S, Yuce Z, et al. Timeline (Bioavailability) of Magnesium Compounds in Hours: Which Magnesium Compound Works Best? Biol Trace Elem Res. 2019;187(1):128-136. doi:10.1007/s12011-018-1351-9
  37. Reddy P, Edwards LR. Magnesium Supplementation in Vitamin D Deficiency. Am J Ther. 2019;26(1):e124-e132. doi:10.1097/MJT.0000000000000538
  38. Magnesium Fact Sheet for Health Professionals. Ods.od.nih.gov. Accessed February 23, 2021.

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